Thank you for your interest. Please note, the purpose of this posting is to recruit for on-going and future positions.

About City of Hope

City of Hope's mission is to deliver the cures of tomorrow to the people who need them today. Founded in 1913,City of Hopehas grown into one of the largest cancer research and treatment organizations in the U.S. and one of the leading research centers for diabetes and other life-threatening illnesses. City of Hope research has been the basis fornumerous breakthrough cancer medicines, as well as human synthetic insulin and monoclonal antibodies. With an independent, National Cancer Institute-designated comprehensive cancer center at its core, City of Hope brings a uniquely integrated model to patients spanning cancer care, research and development, academics and training, and innovation initiatives. City of Hope’s growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, andtreatment facilities in Atlanta, Chicago and Phoenix. City of Hope’s affiliated group of organizations includesTranslational Genomics Research InstituteandAccessHope^TM. For more information about City of Hope, follow us onFacebook,Twitter,YouTube,InstagramandLinkedIn.

City of Hope’s commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary and Key Responsibilities

We are seeking a talented and motivated Postdoctoral Fellow to work in the laboratory of Dr. Srividya Swaminathan in the Department of Systems Biology, City of Hope. We study processes within lymphocytes and those outside (in the immune microenvironment) that drive the development of lymphoid malignancies including B- and T- cell acute lymphoblastic leukemia (ALL) and lymphomas. We apply this to develop therapies that specifically target malignant lymphocytes. Research in our lab spans Hematology, Oncology, and Immuno-Oncology. The Postdoctoral Fellow who joins the team will lead a project focused on specifically targeting diseased immune subsets in systemic lupus erythematosus (SLE) and indolent lymphomas. The Fellow will perform experiments using transgenic and transplantation mouse models of lymphoproliferative diseases, primary cells from patients, humanized mice, gene editing, classical molecular, cell biology, and biochemistry, and single cell sequencing approaches. The Fellow will also contribute to other ongoing immuno-oncology projects in the team.

Recent work:

Recent seminal discoveries made in our lab include:

• the mechanisms and clinical applications of suppressed surveillance by innate immune natural killer cells in patients with ALL (Blood 2021, JITC 2023, STAR Protocols 2021).
• the mechanisms underlying the progression of B cells in autoimmune diseases and indolent lymphomas to diffuse large B cell lymphomas (Communications Biology 2023).

Methods that will be extensively utilized but not limited to are:

• Immune profiling (cytometry, scRNAseq).
• In vivo assays (mouse genetics, intravenous and intrafemoral transplantation assays, subcutaneous pump implantation for delivery of candidate therapies, humanized mouse models, pre-clinical testing of immunotherapies in xenotransplantation models, bioluminescence imaging).
• Molecular biology and biochemistry (retroviral/lentiviral transduction, molecular cloning, high throughput RNA/DNA sequencing, qPCR, immunoblotting, immunofluorescence, Luminex, CRISPR-based gene editing of immune cells).

Basic education, experience and skills required for consideration:

• PhD in Immunology, Cell, Molecular biology, or another field related to Life Sciences.
• Enthusiasm for science, and willingness to think beyond established concepts.
• Experience with flow cytometry.
• Experience performing in vivo procedures in mice.
• Enthusiasm to learn new experimental and computational data analysis tools.
• Highly independent with excellent organizational skills.
• Collaborative team player.
• Good communication skills.

Additional information:

• Your application should include the following in a single PDF emailed to [email protected]:
  • Curriculum Vitae
  • Contacts of three scientific mentors
  • A cover letter highlighting your research interests, a brief statement explaining how your past research ties in with the goals of our laboratory and your future career plans.
• For more information about Dr. Swaminathan’s lab, please visit here.
• Pay Rate: $31.00-$34.23 per hour.
• The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate’s experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.
• As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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