Research Fellow in Cancer Virology

University of Leeds

Leeds, United Kingdom

ID: 7107487 (Ref.No. FBSMB1230)
Posted: August 8, 2022

Job Description

Are you an ambitious researcher looking for your next challenge? Do you have an established background in cancer biology, cell biology or virology? Do you want to further your career in one of the UKs leading research intensive Universities? 

Persistent infection with human papillomaviruses (HPV) is the cause of ~5% of the global cancer burden, including nearly all carcinomas of the cervix, other anogenital sites and the oropharynx. HPVs may also cause skin cancer in the immunosuppressed. You will be joining our internationally recognised research group as part of a Faculty of Biological Sciences funded position to investigate the molecular mechanisms by which HPV expressed oncoproteins transform cells. Our group collaborates extensively with clinical colleagues to ensure maximum translational potential arises from our fundamental biology studies. We will apply a combination of cell biology, biochemical and bioinformatic approaches to clarify the molecular mechanisms by which HPV E5, E6 and E7 target host cell signalling pathways in a range of HPV-driven cancers. Specifically, you will confirm the role of recently identified pathways including those controlling proliferation and inflammation in transformation. These findings will inform the development of new therapeutic strategies targeting host and viral factors. You will also be responsible for developing culture models using primary ano-genital and oral epithelial cells to interrogate the role of signalling pathways in the HPV life cycle.    

You should have a PhD (or close to completion) in virology, cell biology, cancer biology or a closely allied discipline. You should have experience with interrogating the roles of cell signalling pathways in normal cell function and in disease. Experience with primary cell culture is desirable but not essential. 

The University of Leeds and the Faculty of Biological Sciences are committed to providing equal opportunities for all and offer a range of family friendly policies. The University is a charter member of Athena SWAN (the national body that promotes gender equality in higher education), and the Faculty of Biological Sciences was awarded a Silver award in 2020.  We are proud to be an inclusive Faculty that values all staff, and are happy to consider job share applications and requests for flexible working arrangements from our employees. Our Athena SWAN webpage provides more information. 

To explore the post further or for any queries you may have, please contact: 

Andrew Macdonald, Professor of Tumour Virology and Head of the School of Molecular and Cellular Biology

Email: [email protected] 

Location:  Leeds - Main Campus
Faculty/Service:  Faculty of Biological Sciences
School/Institute:  School of Molecular & Cellular Biology
Category:  Research
Grade:  Grade 7
Salary:  £34,304 to £40,927 p.a.
Working Time:  100% - we will consider flexible working arrangements
Post Type:  Full Time
Contract Type:  Fixed Term (12 months)
Release Date:  Friday 05 August 2022
Closing Date:  Friday 19 August 2022
Reference:  FBSMB1230

The University community is made up of a wide range of people with diverse backgrounds and circumstances, which we value and regard as a great asset. As part of our continued commitment to equality and inclusion, we strive to create an environment where everyone can reach their full potential and have a real opportunity to participate in and contribute to our activities.