Postdoctoral Fellow - Cancer Genetics/Epigenetics

City of Hope

Monrovia, CA

ID: 7086050 (Ref.No. 10012149-1)
Posted: September 24, 2021
Application Deadline: Open Until Filled

Job Description

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

Seeking a Postdoctoral to join the lab of Dr. Chun-Wei (David) Chen in Systems Biology focused on the epigenetic mechanisms underlying the therapeutic resistance in cancers. This laboratory is skilled in high-throughput CRISPR genetic screens for de novo therapeutic target discovery. They also utilize next-generation sequencing (NGS) for epigenomic and transcriptomic analyses (ChIPseq, ATACseq, RNAseq, etc.), and the patient-derived xenograft (PDX) models for in vivo therapeutic efficacy assessments. In addition, Dr. Chen's laboratory is involved in cutting-edge technology development including high-density CRISPR protein scan, precision epigenome editing, and single-cell CRISPR/RNA-seq. The lab is well funded by several NIH (R37 MERIT, R01s, U54) and foundation (ASH, LLS, ALSF, COSF, SU2C-CRUK) awards.

Basic education, experience and skills required for consideration:
  • A Ph.D. degree in biomedical sciences, structural biology, computational biology or bioinformatics (required).
  • Good oral and written communication skills in English (required).
  • Experience in cell biology, molecular cloning, or animal model studies (highly preferred).
  • Experience in transcriptomic, proteomic, epigenetic, molecular dynamic, or protein structural data analysis (highly preferred).
  • Experience in protein purification, compound screen, protein/protein or protein/compound interaction (highly preferred).
  • Experience in R, Python, Perl, UNIX/LINUX, etc. (highly preferred).

Additional Information:
  • For more information about Dr. David Chen's research, please click here.
  • List of recent publications, please visit here .
  • To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full vaccination by September 30, 2021. Compliance is a condition of employment.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


  • Posting Date: Jul 26, 2021
  • Job Field: Research
  • Employee Status: Regular
  • Shift: Day Job

City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.


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