Post Doctoral Fellow

Cleveland Clinic

Cleveland, OH

ID: 7075364 (Ref.No. bfaf793f)
Posted: February 23, 2021
Application Deadline: Open Until Filled

Job Description

A NIH-funded postdoctoral fellow position is available in the laboratory of Dr. Dennis Stuehr in the Department of Inflammation and Immunity, Cleveland Clinic, USA. The scientific project aims to uncover the molecular mechanisms of heme trafficking in mammalian cells and the molecular mechanisms of heme insertion into biomedically-important heme proteins including soluble guanylyl cyclase, hemoglobin, myoglobin, cytochrome P450’s, and indoleamine and tryptophan dioxygenases. Our research approach combines biochemical, biophysical, and computational experiments on the purified proteins with confirmatory and exploratory experiments in cultured mammalian cells. Candidates with a recent or upcoming PhD with expertise in protein biochemistry, biophysics, or structural biology are invited to send their CV and names of three references to:

Dr. Dennis Stuehr

For representative articles see:

Heat shock protein 90 associates with the Per-Arnt-Sim domain of heme-free soluble guanylyl cyclase: Implications for enzyme maturation. Sarkar A, Dai Y, Haque MM, Seeger F, Ghosh A, Garcin ED, Montfort WR, Hazen SL, Misra S, Stuehr DJ. (2015) J Biol Chem. 290:21615-28. PMID: 26134567

Heat shock protein 90 regulates soluble guanylyl cyclase by a dual mechanism. Dai Y, Schlanger S, Haque MM, Misra S, Stuehr DJ. (2019) J Biol Chem. 294: 12880-91. PMID: 31311859

Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells. Sweeny EA, Singh AB, Chakravarti R, Martinez-Guzman O, Saini A, Haque MM, Garee G, Dans PD, Hannibal L, Reddi AR, Stuehr DJ. (2018) J Biol Chem. 293:14557-14568. PMID: 30012884.

GAPDH delivers heme to soluble guanylyl cyclase. Dai Y, Sweeny EA, Schlanger S, Ghosh A, Stuehr DJ. J Biol Chem. (2020) 295:8145-8154. PMID: 32358060

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