ID: 7069197 (Ref.No. 1c6b6404)
Posted: August 27, 2020
Application Deadline: Open Until Filled
Novel therapeutic vulnerabilities in prostate cancer
Our group at the Department of Cancer Biology at the Lerner Research Institute of the Cleveland Clinic is seeking a highly motivated and independent post-doctoral fellow to join our studies to overcome treatment resistance in prostate cancer.
Our laboratory focuses on the transcriptional processes and signal transduction cascades that drive lethal prostate cancer progression. Via mechanistic dissection of these pathways and/or complexes, we strive to develop novel therapeutic targets and treatment approaches and to isolate biomarkers of response to these novel treatments. Examples of research interests and recent studies from our NCI-funded research programs include: Wei et al. (European Urology, 2017), Liu et al. (eLife, 2017), Kumari et al. (Endocrine-Related Cancer, 2017), Venkadakrishnan et al. (Oncogene, 2019).
Specific areas of current research interest include:
1) Isolating and targeting critical molecular interactions in AR transcriptional complexes
2) Targeting the action of kinases and identifying kinase substrates that can serve as biomarkers of treatment response
3) Defining the impact of genomic markers on treatment response to personalize the administration of current prostate cancer drugs
All projects involve clinical validation of laboratory findings using archival and fresh patient specimens and animal models of advanced prostate cancer for translational and therapeutic studies.
The ideal candidate is highly motived and driven to succeed in a translational science environment. The candidate should have a recent PhD and expertise in cell biology, molecular biology and preclinical animal studies, and is interested in extrapolating in vitro and in vivo findings to patient specimens and data. Outstanding verbal and communication skills are required. The Cleveland Clinic Lerner Research Institute provides an excellent interactive research environment with access to state-of-the-art equipment and facilities.
Interested applicants should submit a CV and contact information for 3 references to Dr. Hannelore Heemers via email: firstname.lastname@example.org.
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