Postdoctoral Research Scientist (Mitochondrial Degeneration)

Columbia University Department of Surgery

New York, NY

ID: 7064867
Posted: February 24, 2020

Job Description

The Division of Surgical Science of Surgery at Columbia University Vagelos College of Physicians and Surgeons is accepting applications for a Postdoctoral Research Scientist. Individual will be responsible for performance and development of a research project that focuses on cellular and molecular mechanism underlying neuronal and mitochondrial degeneration relevant to basic and translational study in novel transgenic mouse model targeting to mitochondrial proteins including mitochondrial import, mitochondrial dynamics, and permeability transition pore. The recruitment will focus on the study of mitochondrial and synaptic function and neurodegeneration in primary neurons and in brain of in vivo animal model.

Requirements: PhD, MD or both. Experience in biochemistry and molecular biology along with previous experience in research projects related to mitochondrial function and structure changes, analysis of mitochondrial dynamics, fusion and fission, Axonal mitochondrial transport, mitochondrial function, confocal microscopy, mitochondrial and synaptic image and at least 2-3 publication related to diabetes-induced pathophysiology. Ability to work independently after a short training period, experience in write scientific papers and assisting with grant applications.

Responsibilities include: 1) Perform of laboratory research in the area of neurodegeneration and mitochondrial function including mitochondrial and synaptic structure and function alterations. 2) Analysis of mitochondrial function, dynamics, axonal transport, mitochondrial and synaptic morphology, transfection in primary and continuous cell lines, viral transfections in vitro and in vivo. 3) Perform primary mouse neuronal culture, immunostaining/fluorescence and confocal microscopy neuroanatomy and neuropathology in vitro cultured neurons and in vivo brain section.
4) Perform plasmid DNA preparation, immunoblotting and RNA analysis for protein expression and pattern and gene changes. 5) Perform literature searches, manage data, analyze experimental results and published data. Participate to the development of an extramurally funded research program by assisting PIs with NIH grants by developing and generating data and figures.

Columbia University is an Equal Opportunity Employer / Disability / Veteran


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