Postdoctoral Fellow - Circadian Clock Regulation of Metabolism

City of Hope

Duarte, CA

ID: 7058167
Posted: June 24, 2019
Application Deadline: Open Until Filled

Job Description

About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary
Two Postdoctoral Fellow positions are available in the laboratory of Dr. Ke Ma, Associate Professor, at the Diabetes and Metabolism Research Institute within Beckman Research Institute of City of Hope, CA. The Ma lab applies state-of-the-art circadian biology, molecular and cellular biology approaches to diabetes and obesity research, and we have established a unique program in deciphering the signaling mechanisms underlying circadian clock control in metabolic tissue development, growth and functional capacity. We are looking for highly motivated postdoctoral fellows with strong enthusiasm for metabolic disease or stem cell research to study molecular signaling pathways mediating circadian clock functions in adipose depots and skeletal muscle. Ultimately, our goal is to unravel circadian etiologies underlying the current epidemics of metabolic diseases for targeted therapeutic interventions.

Key Responsibilities include:
Utilizing biochemical and molecular biology approaches combined with animal physiology in genetic mouse models, the specific research directions in Ma Lab will explore:
epigenetic signaling networks mediating circadian clock nutrient-sensing function in adipose tissue and skeletal muscle;
circadian clock regulation of stem cell behavior in skeletal muscle development, growth, and regeneration; and
novel roles of circadian regulators in cancer development and metabolism.


Basic education, experience and skills required for consideration:
PhD in Molecular, Cellular or Developmental Biology;
Proficiency with biochemical techniques, molecular biology skills and cell culture systems;
Highly motivated with a proven track record of publications, and astrong interest in metabolic disease, epigenetics, or stem cell research;
Strong work ethic and ability to work effectively in a team.
Preferred education experience and skills:
Experience with in vivo animal model research;
Experience in biochemistry, gene regulation, with epigenetics and stem cell research and particularly genomic bioinformatics analysis;
Technical skills in metabolic, epigenetics, and stem cell research.
Additional Information:
For a list of lab publications, please click here.
For more information about Dr. Ma’s research, please click here.
Please include a brief research statement and list of three references with your application.
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.



 

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