Research Associate

University of Virginia

Charlottesville, VA

ID: 7055737
Posted: February 5, 2019
Application Deadline: Open Until Filled

Job Description

My laboratory is working on the development of small molecule inhibitors of transcription factors that are drivers in cancer. We recently developed a small molecule inhibitor targeting the CBFB-SMMHC fusion protein that is a driver in ~8% of acute myeloid leukemia (AML) cases ((Illendula et al. Science 347(6223):779-84 (2015); Pulikkan et al. Cell 174(1):172-186 (2018)). This compound has been licensed to Systems Oncology and is being developed for clinical evaluation. We have also developed small molecule inhibitors targeting the wildtype CBFB-RUNX interaction (Illendula et al. EBioMedicine 8:117-131 (2016)) and shown these are effective in a number of cancer contexts including leukemia (Illendula et al. EBioMedicine 8:117-131 (2016), Choi et al. Blood 130(15):1722-1733 (2017)), multiple myeloma (Zhou et al. Leukemia, in press), triple negative breast cancer (TNBC) (Illendula et al. EBioMedicine 8:117-131 (2016)), and ovarian cancer (Carlton et al. Gynecol. Oncology 149(2):350-360 (2018)).

We are seeking an experienced medicinal/synthetic chemist to work on an NIH funded grant focused on our CBFB and CBFB-SMMHC transcription factor inhibitors. I am writing to you to make you aware of this opportunity in case you would like to apply and also to ask you to pass this along to any colleagues who may be interested.

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