Postdoctoral Positions in Cancer Stem Cell Research at Northwestern University, Chicago, USA

Northwestern University Feinberg School of Medicine

Chicago, IL

ID: 7049437
Posted: January 5, 2018
Application Deadline: Open Until Filled

Job Description

Postdoctoral Positions in Cancer Stem Cell Research
NORTHWESTERN UNIVERSITY FEINBERG SCHOOL OF MEDICINE

Postdoctoral positions for studying cancer stem cells are available at Dr. Shi-Yuan Cheng’s laboratory at Northwestern University Feinberg School of Medicine in Chicago, IL, USA. The Cheng Laboratory investigates molecular mechanisms that control malignant phenotype and therapy responses of brain glioblastoma (GBM) using patient-derived cancer stem cells, PDX and other model systems, and techniques of biochemical, molecular, cellular and bioinformatics. Cheng laboratory is currently supported with 3 NIH R01s, a MPI R21, and multiple research awards from other funding agencies. We are seeking highly motivated postdoctoral candidates who are interested in studying the following research areas:

1. Methylation of DNA and histone in cancer genome are determinants for cancer phenotype and malignancy. We are profiling DNA methylation and non-coding RNAs in clinical GBM tumor specimens and GSCs. We will analyze these new data and interrogating public and TCGA database. We are studying mechanisms by which dys-regulated DNA and histone methylation, and non-coding RNA control cancer phenotype and response to therapies.

2 Protein post-translation modification: phosphorylation, acetylation and non-histone methylation of proteins are key events in modulating cellular signaling and cellular function. We have identified novel sites of protein phosphorylation, acetylation arginine methylation by proteomics and substrate-guided approach in GSCs. We are interested in studying mechanisms by which these protein post-translational modifications modulate GBM phenotype and response to therapies.

3. Autophagy, DNA damage repair and response, cancer cell invasion/motility and OTHER cellular process are also found active in GSCs and controlling GBM phenotype and therapy-responses. We are interested in studying mechanisms by which these biological processes are regulated, thereby modulating cancer malignancy and responses to therapies.

The applicants should have a PhD degree in no more than two years in biochemistry, molecular biology and well-trained with proficient skills in studying cellular signaling, protein post-modifications and gene regulation. The applicants must have very strong publication records with first-author papers in high-impact journals and must be highly motivated with the drive to succeed. The applicants must be able to design and conduct experiments, prepare and present their researches at scientific conference; write and edit/revise research manuscripts and grant proposals, and proficient in English communications.

Selected publications of Cheng laboratory from 2011 to 2017:
1. 2011, J. Clin. Invest. 121(3):905-917
2. 2011, J. Clin. Invest. 121(12):4670–4684.
3. 2012, Oncogene, 31(21):2691-702.
4. 2012, Proc. Natl. Acad. Sci., USA, 109(8):3018-23.
5. 2013, Proc. Natl. Acad. Sci., USA, 110(21):8644-9
6. 2014, Oncogene, 33(19):2504-12;
7. 2014, J Clin. Invest., 124(9):3741-56.
8. 2015, Neuro-Oncology, 17(6):832-42
9. 2016, Nature Comm., 8(1):1454
10. 2017, Proc. Natl. Acad. Sci., USA, 114(31):8366-8371.
11. 2017, Nat Commun. Nov 13;8(1):1454.
12. 2017, Cancer Cell, 32(6):840-858

Please submit a letter of interest, your resume, reprints of relevant publications, and name and contact information of three references. A NIH-standard salary for postdoctoral researchers ($47,848/first year with 0 year of postdoctoral experience, https://grants.nih.gov/grants/guide/notice-files/NOT-OD-17-003.html) with an excellent compensation and benefits package will be provided.

Northwestern University is an Equal Opportunity/Affirmative Action Educator and Employer and invites applications from all qualified individuals. Applications from women and minorities are especially sought.

Contact:
Shi-Yuan Cheng, PhD
Professor & Zell Scholar
The Ken and Ruth Davee Department of Neurology
& Northwestern Medicine Lou and Jean Malnati Brain Tumor Institute
The Robert H. Lurie Comprehensive Cancer Center
Northwestern University Feinberg School of Medicine
303 E. Superior, Lurie 6-119
Chicago, IL 60611, USA
Office:  1-(312)503-3043
Lab: 1-(312)503-5413
Fax:      1-(312)503-5603
E-mail:  shiyuancheng@gmail.com
Lab website: http://labs.feinberg.northwestern.edu/cheng/

Northwestern University is an Equal Opportunity/Affirmative Action Educator and Employer and invites applications from all qualified individuals. Applications from women and minorities are especially sought.



 

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